Lipopeptides for Vaccine Development

The development of lipopeptides (lipidated peptides) for vaccines is discussed, including their role as antigens and/or adjuvants. Distinct classes lipopeptide architectures are covered simple linear and ligated constructs lipid core peptides. design, synthesis, immunological responses the important class glycerol-based Toll-like receptor agonist such Pam3CSK4, which contains three palmitoyl chains a CSK4 hexapeptide sequence, many derivatives this model immunogenic compound also reviewed. Self-assembled structures spherical worm-like micelles that have been shown to act vaccine agents described. work discussed includes examples developed with antigens, well immunotherapies treat infectious diseases malaria, influenza, hepatitis, COVID-19, others, cancer immunotherapies. Some these proceeded clinical development. research highlights huge potential of, diversity roles for, in contemporary future